Treatment for Hemorrhoids

Treatment of Chronic Venous Disease


Diosmin + Hesperidin 500 vs Daflon 1000

What are the differences between Diosmin Hesperidin 500 and Daflon 1000?

  1. Composition
  2. Dosage
  3. Safety Profile
  4. Effectiveness
  5. Convenience

Most people who have experienced venous diseases like chronic venous disorders (CVD) or hemorrhoids should be familiar with Diosmin Hespridin 500. It has long been proven to be effective in treating such disorders while being available for purchase over the counter. While its use is highly recommended, it can become troublesome for some patients, especially those who have trouble swallowing.

To make for a better alternative, Diosmin + Hesperidin1000 is being introduced to the market, still being a micronized purified flavonoid fraction (MPFF) drug. Looking at the differences between Diosmin + Hesperidin 500 vs Daflon 1000, we’ll see which of the two is better to use.

We’ve compiled some differences (and some similarities) between Diosmin Hesperidin 500 and Diosmin + Hesperidin (Daflon 1000). Keep reading to learn more.



The most obvious difference between the two is their composition.2 Take a look at the following table:

Diosmin Hespridin 500 versus Daflon 1000

  Diosmin Hespridin 500 Daflon 1000
Diosmin 450 mg 900 mg
Flavonoids expressed as hesperidin 50 mg 100 mg

Here, we see how the components of MPFF are distributed. Since Diosmin + Hesperidin (Daflon 1000) has a bigger dose, both its diosmin and hesperidin contents are greater than that of Diosmin Hesperidin 500. This will affect how many tablets the patient needs to take in a day.

how to take daflon



The general dosage for Daflon is 1000 mg every day if you’re treating venous diseases. If you’re treating acute hemorrhoidal attacks, you would need a daily 3000 mg dose for the first 4 days, and 2000 mg per day for the following 3 days.2

Achieving this dosage with Diosmin Hesperidin 500 means you have to take 2 tablets daily for venous diseases, and 6 and 4 tablets daily for acute hemorrhoidal attacks respectively. Diosmin + Hesperidin (Daflon 1000) translates this into 1 tablet daily for venous diseases and 3 and 2 tablets for hemorrhoids.

Both tablets are administered only through the oral route and should be taken at mealtimes. If prescribed by a doctor, follow their recommendations.


Safety Profile

Being composed of the same materials, both medicines have similar safety profiles.

Contraindications1, 2: Patients who are hypersensitive to the active substance or any of its excipients should avoid taking either medicine.

Precautions1, 2: Using Daflon for hemorrhoids does not inhibit any treatment for other anal conditions. If symptoms persist after 15 days, the patient should consult a doctor for a proper proctological exam and review of treatment.

Breastfeeding1, 2: While it is unknown whether the substances in Diosmin Hesperidin 500 are excreted in human milk, the risk for infants should not be excluded. The patient and the doctor must then come to a decision whether to discontinue breastfeeding or Daflon treatment. For Diosmin + Hesperidin (Daflon 1000), it is recommended to avoid breastfeeding altogether.

Side Effects1, 2: Common side effects for both drugs include diarrhea, dyspepsia, nausea, and vomiting. An uncommon side effect is colitis or inflammation of the colon. Rare side effects include dizziness, headaches, malaise, rashes, pruritus, and urticaria. Some of the lesser-known side effects are abdominal pain and isolated face, lip, eyelid edema. An exceptionally rare side effect is Quincke’s edema. Diosmin Hesperidin 500 is often welltolerated and side effects are rare. Patients are encouraged to report possible side effects that are not listed here.

Overdosage1, 2: Daflon overdosage has a limited experience. Cases of overdosage with Diosmin Hesperidin 500 caused adverse effects such as diarrhea, nausea, abominable pain, pruritus, and rash. Meanwhile, no cases of overdose from Diosmin + Hesperidin (Daflon 1000) have been reported. If you take more than the recommended amount of Daflon, consult a doctor immediately.

daflon effectiveness



Both are effective at treating venous circulation disorders and hemorrhoids and symptoms of acute hemorrhoidal attacks. A non-inferiority study has been conducted between Diosmin Hesperidin 500 mg and a 1000 mg suspension of Daflon for symptomatic venous disorders. Its results showed similar improvement to the quality of life and reduction of symptoms.4 Take note that severe cases of hemorrhoids would need medical intervention. If Daflon intake does not reduce your symptoms, visit your doctor immediately.



The advantage of Diosmin + Hesperidin (Daflon 1000) is that it’s more convenient to take. Needing fewer doses in a day (half of what’s needed for Diosmin Hespridin 500), patient adherence is expected to improve. Symptoms of either CVD or hemorrhoids will also be easier to manage with Diosmin + Hesperidin (Daflon 1000) than Diosmin Hespridin 500.4

Both medicines are over-the-counter drugs that don’t need a prescription. If you need to take them for hemorrhoids or CVD, Diosmin + Hesperidin (Daflon 1000) is available in drugstores nationwide.

Key Takeaway

In comparing Diosmin Hesperidin 500 vs Daflon 1000, we see that while both are effective at treating venous disorders and hemorrhoids, the latter has more advantages. Taking Diosmin + Hesperidin (Daflon 1000) will be more convenient for the patient when it comes to administration and cost.

To learn more about Diosmin + Hesperidin (Daflon 1000) and why it has certain advantages over Diosmin Hespridin 500, you can read the product overview here. To get some answers to frequently asked questions, visit this link. If you want to connect with us, we’re willing to answer your questions about Daflon and hemorrhoids. Just contact us here.